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the study of the effect of a drug on well being of patient during and immediately after operation

Effect Of Dexmedetomidine On Serum Cortisol Level And Perioperative Haemodynamics In Children Undergoing Elective Ophthalmic Surgery â?? A Prospective, Randomized, Comparative Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/01/006568
Enrollment
40
Registered
2016-01-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: null- squint,retinal detachment etc.

Interventions

Intervention1: Dexmedetomidine: children will receive a bolus dose of dexmedetomidine at the rate of 0.5 mcg/kg over 10 minutes and then continuous infusion at the rate of 0.5 mcg/kg/hr till the end o

Sponsors

Dr Renu Sinha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: â¦? Age: 8 â?? 14 years and ASA I/II â¦? Elective ophthalmic surgeries â¦? Duration of surgery >45 minutes â¦? Written informed consent from parent and assent from children

Exclusion criteria

Exclusion criteria: � Cardiac, hepatic and renal diseases � Mental retardation � Premedication with sedatives � Surgeries � Consent refusal

Design outcomes

Primary

MeasureTime frame
� To compare the rise of serum cortisol and blood glucose levels perioperatively in children receiving dexmedetomidine infusion along with conventional general anaesthesia and in children receiving conventional general anaesthesia.Timepoint: The blood samples for estimating blood sugar and serum cortisol will be taken 1 day prior to surgery for baseline values, 45 minutes post induction and 1 hour after completion of surgery

Secondary

MeasureTime frame
� To compare haemodynamic stability based on heart rate, systolic blood pressure, diastolic blood pressure, oxygen saturation in the two groupsTimepoint: during the intra operative period.;� To compare incidence of emergence agitation in the two groups.Timepoint: at 0, 10 and 20 minutes post operatively.;�To compare incidence of pain in the two groups.Timepoint: at 0, 10, 20 minutes and at 1, 2 and 4 hours post operatively.

Countries

India

Contacts

Public ContactDr Renu Sinha

All India Institute of Medical Sciences

sangamthecool@gmail.com8527698954

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026