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A clinical trial to study the effect of phenylephrine, a drug that increases blood pressure, to prevent decrease in blood pressure following oxytocin injection during planned caesarean section

Efficacy of phenylephrine to prevent haemodynamic responses of oxytocin during elective caesarean section â?? a randomized, double-blind, controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/01/006548
Enrollment
66
Registered
2016-01-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Oxytocin induced hypotension and tachycardia

Interventions

Intervention1: Group P: Phenylephrine 100 μg in 1 ml volume will be injected before oxytocin administration Control Intervention1: Group S: Normal saline 1 ml will be injected before oxytocin adminis

Sponsors

University College of Medical Sciences and Guru Teg Bahadur Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Healthy term pregnant patients undergoing elective caesarean section under spinal anaesthesia • Uncomplicated, singleton pregnancy

Exclusion criteria

Exclusion criteria: • Patients in active labour • Ruptured membranes • Known drug allergy to oxytocin • Maternal complications e.g. pre-eclampsia, diabetes mellitus, cardiovascular disease, cerebrovascular disease • Known risk factors for postpartum haemorrhage e.g. Multiple gestation, abnormal placentation, uterine fibroid, macrosomia, hydramnios, history of postpartum haemorrhage or uterine atony • Patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, autonomic neuropathy, spinal deformities, other neurological diseases or hypovolemia due to any cause

Design outcomes

Primary

MeasureTime frame
Peak changes in mean arterial pressure and heart rateTimepoint: Peak changes in mean arterial pressure and heart rate

Secondary

MeasureTime frame
a)Changes in systolic blood pressure and diastolic blood pressure b)Any complications observed Timepoint: a)Initial 3 minutes following oxytocin administration b)After delivery

Countries

India

Contacts

Public ContactDr Medha Mohta

University College of Medical Sciences and Guru Teg Bahadur Hospital

drvijay5725@gmail.com9873414425

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026