COMPARISON OF THREE DIFFERENT DOSES OF FENTANYL TO PREVENT HEMODYNAMIC STRESS RESPONSE DURING INTUBATION

â??CLINICAL EVALUATION OF EFFICACY AND SAFETY OF THREE DIFFERENT DOSES OF FENTANYL TO PREVENT HAEMODYNAMIC STRESS RESPONSE DURING LARYNGOSCOPY AND INTUBATION: A RANDOMIZED DOUBLE BLIND CLINICAL STUDYâ??

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2016/01/006519

Enrollment

Registered

2016-01-14

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- POSTED FOR ELECTIVE SURGERY

Interventions

Intervention1: inj.fentanyl: 2mcg/kg,3mcg/kg,and 4mcg/kg of fentanyl intravenously as a sigle dose five minute before induction of anaesthesia. Control Intervention1: inj fentanyl: 2mcg/kg,3mcg/kg and

Eligibility

Inclusion criteria

Inclusion criteria: • Age: 18 to 40 years. • Gender: Either gender. • Patients posted for elective surgery under general anaesthesia requiring endotracheal intubation. • Duration of surgery up to 2 hrs. • ASA physical status I and II. • BMI • Informed written consent for participation in study.

Exclusion criteria

Exclusion criteria: • Patients with diabetes, COPD, renal disease, cardiac diseases like IHD, hypertension, valvular heart disease, AV conduction block, aortic stenosis, left ventricular failure, etc. • Patients on drugs having effects on heart rate and blood pressure (sedatives, opioids, Î²-blockers, calcium channel blockers, diuretics) and anti-psychiatric drugs. • Pregnant women and lactating mothers. • Anticipated difficult intubation. • Intubation attempt lasting longer than 15 seconds.

Design outcomes

Primary

Measure	Time frame
1. To assess the efficacy and safety of three different doses of fentanyl in attenuating haemodynamic stress response to laryngoscopy and endotracheal intubation.Timepoint: at baseline, 5minutes after fentanyl administration, at the time of intubation, and then at 1,3,5,10,15 and 20 minutes after intubation.	—

Secondary

Measure	Time frame
To assess the sedative effect of fentanyl. 2. To observe complication if any, in three groups. Timepoint: at baseline, 5minutes after fentanyl administration, at the time of intubation, and then at 1,3,5,10,15 and 20 minutes after intubation,intraoperative period,at the time of extubation and postoperative upto 120 minutes	—

Countries

India

Contacts

Public ContactDR DCTRIPATHI

GOVERNMENT MEDICAL COLLEGE AND SIR TAKHTSINHAJI GENERAL HOSPITAL

drtripathi1961@yahoo.co.in9428408718

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026