A clinical trial to evaluate and compare the level of nitric oxide in serum and saliva of smokers and non smokers with periodontal disease before and after oral hygiene measures ( professional teeth cleaning) .

Evaluation of Nitric oxide levels in the serum and saliva in smokers and non smokers with chronic periodontitis before and after phase I therapy

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2016/01/006511

Enrollment

Registered

2016-01-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Scaling and root planing: In this trial levels of nitric oxide are measured in serum and saliva of smokers and non smokers with periodontitis before and after scaling and polishing Inte

Eligibility

Inclusion criteria

Inclusion criteria: Individuals with a minimum of 20 teeth will be enrolled in the study. 1. Group I a. Chronic periodontitis patients with more than 30% of sites with the presence of a PPD of >= 5mm and CAL of >= 5mm. b. Patients with no history of smoking. 2. Group II a. Chronic periodontitis patients with more than 30% of sites with the presence of a PPD of >= 5mm and CAL of >= 5mm. b. Patients with history of smoking at least 10 cigarettes per day for the last 3 years.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: 1. Pregnant women or lactating mothers. 2. Subjects who have undergone any periodontal therapy in the past 6 month. 3. Subjects on antibiotics, anti-inflammatory therapy, or vitamin/nutritional supplements. 4. Subjects with systemic diseases such as diabetes mellitus, hyperten-sion, renal disease, rheumatoid arthritis, periapical infection of any tooth, or any other form of systemic inflammatory inÂ¬volvement

Design outcomes

Primary

Measure	Time frame
To evaluate the levels of NO in serum and saliva in smokers and nonsmokers with chronic periodontitis and to compare them with periodontally healthy controls & to study the effects of Phase - I periodontal therapy on these levels. Timepoint: To evaluate the levels of NO in serum and saliva in smokers and nonsmokers with chronic periodontitis and to compare them with periodontally healthy controls & to study the effects of Phase - I periodontal therapy on these levels.	—

Measure

Time frame

To evaluate the levels of NO in serum and saliva in smokers and nonsmokers with chronic periodontitis and to compare them with periodontally healthy controls & to study the effects of Phase - I periodontal therapy on these levels. Timepoint: To evaluate the levels of NO in serum and saliva in smokers and nonsmokers with chronic periodontitis and to compare them with periodontally healthy controls & to study the effects of Phase - I periodontal therapy on these levels.

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Secondary

Measure	Time frame
1. To evaluate the level of NO in serum and saliva in smokers and non smokers with chronic periodontitis. 2. To evaluate the level of NO in serum and saliva in smokers and non smokers with chronic periodontitis after Phase I therapy. 3. To compare the level of NO pre and post Phase - I periodontal therapy Timepoint: 1. To evaluate the level of NO in serum and saliva in smokers and non smokers with chronic periodontitis. 2. To evaluate the level of NO in serum and saliva in smokers and non smokers with chronic periodontitis after Phase I therapy. 3. To compare the level of NO pre and post Phase - I periodontal therapy	—

Measure

Time frame

1. To evaluate the level of NO in serum and saliva in smokers and non smokers with chronic periodontitis. 2. To evaluate the level of NO in serum and saliva in smokers and non smokers with chronic periodontitis after Phase I therapy. 3. To compare the level of NO pre and post Phase - I periodontal therapy Timepoint: 1. To evaluate the level of NO in serum and saliva in smokers and non smokers with chronic periodontitis. 2. To evaluate the level of NO in serum and saliva in smokers and non smokers with chronic periodontitis after Phase I therapy. 3. To compare the level of NO pre and post Phase - I periodontal therapy

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Countries

India

Contacts

Public ContactDr Rajashri Kolte

PG Guide

drrajashrikolte@gmail.com09011071468

Outcome results