Health Condition 1: null- Lupus Nephritis
Conditions
Interventions
Intervention1: Oral Prednisolone (0.5 mg/kg/day): intravenous methyl prednisolone (750 mg) for 3 days after which they would receive 0.5 mg/kg/day of oral prednisolone for a period of 8 weeks followed
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: • With a diagnosis of SLE as per American College of Rheumatology (ACR) criteria • Biopsy proved LN (ISN/RPS class III, IV, III+V or IV+V)
Exclusion criteria
Exclusion criteria: â?? Pregnancy/lactation â?? Presence of crescents > 50% of the sampled glomeruli â?? On-going infection â?? Hepatitis B, C or human immunodeficiency virus-I/II infection â?? Prior use of steroids/ immunosuppressive medication for any indication â?? Serum creatinine > 2 mg/dl â?? Neurological or pulmonary lupus â?? History of Diabetes mellitus (DM) â?? Abnormal liver function tests â?? Drug-induced lupus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment responseTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete/partial remission, SELENA-SLEDAI score, QOL, serological remission and adverse events.Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactRaja Ramachandran
PGIMER
Outcome results
None listed