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A clinical trial to compare efficacy of nebulisation with hypertonic saline and epinephrine in children with Acute Bronchiolitis

COMPARATIVE EFFICACY OF HYPERTONIC(3%) SALINE VERSUS EPINEPHRINE NEBULISATION IN CHILDREN WITH ACUTE BRONCHIOLITIS- A RANDOMISED CONTROLLED TRIAL

Status
Unknown
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/12/006458
Enrollment
64
Registered
2015-12-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- presenting with first episode of wheeze with fever or cough. age group from 1 month to 5 years

Interventions

Intervention1: Epinephrine: nebulisation with epinephrine to be given to the subjects Control Intervention1: Hypertonic 3% sodium chloride: nebulisation to be given with 3% sodium chloride (3 ml) in t

Sponsors

BPKIHS
Lead Sponsor
DEPARTMENT OF PAEDIATRICS BP Koirala Institute of Health Sciences
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: All children between 1 month and 5 years of age with the diagnosis of acute bronchiolitis. Bronchiolitis taken as the first episode of wheezing associated with clinical evidence of viral infection (cough, coryza or fever).

Exclusion criteria

Exclusion criteria: children over 5 yrs of age • not giving consent • Multiple episodes of wheezing • Children already on bronchodilators or any other medication • Children with history of allergic rhinitis, atopic dermatitis. • Children with cardiac disease • Children with chronic pulmonary disease • Children with obtunded consciousness • Children with progressive respiratory failure.

Design outcomes

Primary

MeasureTime frame
to compare the efficacy of the nebulisation with ephrinephrine to hypertonic salineTimepoint: to compare the efficacy of the nebulisation with ephrinephrine to hypertonic saline

Secondary

MeasureTime frame
to compare the safety of nebulisation with epinephrine and hypertonic salineTimepoint: 1 year

Countries

Nepal

Contacts

Public ContactDr Rohan R Verma

BPKIHS

drrohanverma86@yahoo.com9807060479

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026