A clinical trial to study the effects of trichloroacetic acid in tympanic membrane perforation and in improvement of hearing.

Effficacy of chemical cauterization in tympanic membrane perforation; a prospective study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/12/006423

Enrollment

Registered

2015-12-08

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Tympanic Membrane Perforation

Interventions

Intervention1: trichloroacetic acid: it was applied topically with a probe over the margin of the tympanic membrane perforation under microscopic vision. repeated every 2 weekly for 4 times and the ef

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with central perforation of tympanic membrane following infective or traumatic perforations of tympanic membrane. 2. Ear must be dry for at least 4 weeks. 3. Patient should have pure conductive type of hearing loss.

Exclusion criteria

Exclusion criteria: 1. History of previous ear surgery 2. Attico-antral disease 3. Active discharge 4. Nasopharyngeal pathology 5. Eustachian tube dysfunction 6. Active rhinosinusitis 7. pure sensoryneural hearing loss

Design outcomes

Primary

Measure	Time frame
improvement in hearing and reduction in size of perforationTimepoint: 8 weeks	—

Secondary

Measure	Time frame
complete healing of tympanic membrane perforationTimepoint: 8 weeks	—

Countries

India

Contacts

Public ContactParth B Makwana

Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar

sushilgjha@yahoo.ca09426909700

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026