Effects of Curcumin along with Radiotherapy of Oral Cancer

Effect of Curcumin on Radiation induced Oral Mucositis: A randomised controlled trial - ROMAC TRIAL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/12/006413

Enrollment

Registered

2015-12-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- â?¢Post surgical resection cases of Carcinoma Buccal Mucosa, Gingiva/Alveolus, Retromandibular Trigone, Oral Tongue, Lips, Floor of Mouth, Hard Palate â?¢Histology proven Squamous cell carcinoma

Interventions

Intervention1: Curcumin BCM95 (1000mg/day): Capsules Curcumin BCM95 (1000mg/day) per Oral for 6 weeks with Radiotherapy Intervention2: Placebo: Capsules Placebo daily for 6 weeks Intervention3: Curcum

Eligibility

Inclusion criteria

Inclusion criteria: • Post surgical resection cases of Carcinoma Buccal Mucosa, Gingiva/Alveolus, Retromandibular Trigone, Oral Tongue, Lips, Floor of Mouth, Hard Palate • Histology proven Squamous cell carcinoma • Age >18 years to • WHO Performance Status 0-1 • No prior history of Radiotherapy to head neck region

Exclusion criteria

Exclusion criteria: • Primary Site of Oropharynx, Nasopharynx, Larynx • History of previous Radiotherapy to head neck region • Histopathology other than squamous cell carcinoma

Design outcomes

Primary

Measure	Time frame
To determine whether supplementation of curcumin reduces the severity of Oral Mucositis in patients receiving radiotherapy for Oral CancersTimepoint: One year from enrollment of the first patient	—

Secondary

Measure	Time frame
TO DETERMINE THE QUALITY OF LIFETimepoint: 6 WEEKS PER PATIENT	—

Countries

India

Contacts

Public ContactDr Tej Prakash Soni

Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur

drtejprakashsoni@yahoo.co.in9602240611

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 15, 2026