Health Condition 1: null- Suffering from perforation peritonitis for which they are and undergoing emergency laparotomy
Conditions
Interventions
Intervention1: Group PV (protective intraoperative mechanical ventilation): Ventilation with 6 ml/kg of ideal body weight
alongwith 10 cmH2) of PEEP)
Control Intervention1: Group CV (Conventional intraoperative mechanical ventilation): Ventilation with 10 ml/kg of Ideal Body Weight
Sponsors
University College of Medical Sciences and GTB Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Suffering from intestinal perforation peritonitis scheduled for emergency laparotomy under general anaesthesia.
Exclusion criteria
Exclusion criteria: History of immunosuppression, chronic illness, recent exposure to mechanical ventilation, postoperative mechanical ventilation requirement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SOFA score and IL-6 measurementTimepoint: SOFA score: Daily, upto 7 days postoperatively. IL-6: Baseline (prior to ventilation, 1 hour later and 18 hours postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital mortality and TNF alpha along with procalcitonin and CRP.Timepoint: In-hospital mortality: anytime during Hospital stay postoperatively. Cytokines and mediators: Baseline, 1 hour after ventilation and postoperatively. | — |
Countries
India
Contacts
Public ContactDR Asha Tyagi
Outcome results
None listed