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USEFULNESS OF N - ACETYL CYSTEINE IN LIVE DONOR LIVER TRANSPLANTATION

ROLE Of N-ACETYLCYSTEINE INFUSION IN LIVE DONOR LIVER TRANSPLANTATION. A PROSPECTIVE DOUBLE BLIND RANDOMIZED CONTROL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/12/006401
Enrollment
50
Registered
2015-12-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K746- Other and unspecified cirrhosis ofliver Health Condition 2: null- Patients with chronic liver disease undergoing live donor liver transplantation and their donors(As recipient-donor pairs) are included in the study

Interventions

Intervention1: N-ACETYLCYSTEINE: infusion during donor hepatectomy(In donor) and recipient surgery(in recipient) and also during post-operative period for 96 hours in recipient Control Intervention1:

Sponsors

MOHAMED ABDULLATHEEF TK
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All Living donor pairs undergoing liver transplantation during the period of study who are willing to participate in the study.

Exclusion criteria

Exclusion criteria: 1. ABO incompatible liver transplants 2. Liver transplantations in which the recipient age is less than 18

Design outcomes

Primary

MeasureTime frame
Initial Poor Graft functionTimepoint: 5 days—

Secondary

MeasureTime frame
Hepatic artery or portal vein thrombosisTimepoint: Any time during 30 days after liver transplantation;Length of ICU stayTimepoint: Duration of ICU stay;Liver enzymesTimepoint: peak levels of AST and ALT within the first 7 postoperative days;MortalityTimepoint: 30 days;Post operative bleedingTimepoint: Within 24 hours;Primary non-functionTimepoint: 10 days;Prothrombin time and INRTimepoint: preoperative, postoperative at day 5 and day 10, peak and median level over the first 14 postoperative days;Serum bilirubinTimepoint: preoperative, postoperative at day 5 and day 10, peak and median level over the first 14 postoperative days;Serum creatinineTimepoint: preoperative, postoperative at day 5 and day 10, peak and median level over the first 14 postoperative days;Significant renal Function deterioration deteriorationTimepoint: Within 30 days of Liver transplantation—

Countries

India

Contacts

Public ContactMOHAMED ABDULLATHEEF T K

Sudhamayi Hospitals and Clinics

sudhi@aims.amrita.edu

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026