Health Condition 1: null- schizophrenia patients
Conditions
Interventions
Intervention1: repetitive transcranial magnetic stimulation (rTMS): 20Hz, 5 sessions per week for the duration of 4 weeks.
Control Intervention1: Sham TMS: Rotation of the coil at 90 degree angle to t
Sponsors
Nand Kumar
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients meeting the ICD 10 clinical criteria for schizophrenia with an illness duration of at least 1 year. 2. Patients currently stabilized on same antipsychotics for a period of at least 4 weeks but have significant negative symptoms as assesed on PANSS negative symptom score being greater than equals to 15. 3. Patients or primary caregiver with capacity and willingness to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of co morbid Axis I disorders (using MINI) including substance abuse or dependence (other than caffeine or nicotine). 2. Any history of seizure except those therapeutically induced by ECT. 3. History of treatment with rTMS therapy. 4. Patients receiving or received any surgical procedures on brain. 5. Patients with implanted device or metal in the brain or head or cardiac pacemaker. 6. Facial tattoos with metallic or magnetic sensitive ink. 7. Known or suspected pregnancy 8. History suggestive of increased intracranial pressure; Space occupying brain lesion; History of cerebrovascular accident; Transient ischemic attack within two years; Dementia; Parkinson disease; Huntington chorea; or Multiple sclerosis as assessed clinically.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in negative symptoms and cognitive functionsTimepoint: 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactNand Kumar
AIIMS, New Delhi
Outcome results
None listed