If the drug Mannitol is not given to the kidney donor during the removal of the kidney, does it adversely affect short term function of the kidney in the patient receiving the kidney?

Withholding Mannitol in donor nephrectomy- Does it affect short-term allograft function? - -

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/11/006371

Enrollment

Registered

2015-11-19

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Renal transplant recipients.

Interventions

Intervention1: Witholding the drug Mannitol.: Mannitol will not be administered during donor nephrectomy in the intervention arm. Control Intervention1: Administering Mannitol: 100 ml of 20% Mannitol

Eligibility

Inclusion criteria

Inclusion criteria: All adults undergoing renal transplantation at CMC Vellore will be included after informed consent.

Exclusion criteria

Exclusion criteria: Age >70 years, recipient BMI >30 kg/m2, multiple renal arteries in donor.

Design outcomes

Primary

Measure	Time frame
Serum creatineTimepoint: Day 7 post renal transplant.	—

Secondary

Measure	Time frame
Histopathological evidence of acute tubular necrosis.Timepoint: 1. After the completion of vascular anastomosis in renal transplant. 2. In case biopsy is performed as a result of suspected rejection in the first week after transplant.;Need for dialysisTimepoint: First week post transplant.;Serum creatinineTimepoint: Day 30 post transplant.;Serum cystatinTimepoint: Pre-op, day 1 and day 3 post transplant.;Urine NGAL (Neutrophil Gelatinase-Associated Lipocalin).Timepoint: 18 hrs post transplant.	—

Measure

Time frame

Histopathological evidence of acute tubular necrosis.Timepoint: 1. After the completion of vascular anastomosis in renal transplant. 2. In case biopsy is performed as a result of suspected rejection in the first week after transplant.;Need for dialysisTimepoint: First week post transplant.;Serum creatinineTimepoint: Day 30 post transplant.;Serum cystatinTimepoint: Pre-op, day 1 and day 3 post transplant.;Urine NGAL (Neutrophil Gelatinase-Associated Lipocalin).Timepoint: 18 hrs post transplant.

—

Countries

India

Contacts

Public ContactAntony Devasia

Christian Medical College Vellore

antondevasia@gmail.com04162282055

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026