The effect of intrathecal morphine in reducing intraoperative and postoperative pain in patients undergoing laparoscopic hysterectomy

THE SAFETY AND EFFICACY OF LOW DOSE INTRATHECAL MORPHINE FOR LAPAROSCOPIC HYSTERECTOMY , A DOUBLE BLINDED RANDOMIZED CONTROLLED TRIAL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/11/006370

Enrollment

Registered

2015-11-19

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing total laparoscopic hystrectomy under general anaesthesia

Interventions

Intervention1: Group M: These patients received sub-arachnoid block with 5mg bupivacaine and 200Î¼g morphine L3-4 interspace observing standard aseptic technique once before induction of general anaes

Eligibility

Inclusion criteria

Inclusion criteria: ASA I or ASA II patients undergoing laparoscopic hysterectomy

Exclusion criteria

Exclusion criteria: • Inability to provide informed consent • Refusal for spinal anaesthesia • Morbid obesity • Coagulation disorders or treatment with anticoagulants • Severe spinal deformities • Infection at the injection site • Symptomatic cardiac and respiratory disease • Chronic analgesic use • Not capable of understanding PCA device use • Undergoing concurrent laparoscopic procedures

Design outcomes

Primary

Measure	Time frame
1. To determine the efficacy of intrathecal morphine for perioperative analgesia in patients undergoing total laparoscopic hysterectomy by its effect on VAS. 2. To assess the effect of intrathecal morphine on perioperative endocrine stress markers compared with fentanyl infusion.Timepoint: 1.The first pain assessment was done as soon as the patient was awake, oriented and capable of following commands. VAS scoring was done 2-hourly for 8 hours and at 24 hours. 2.Blood samples for stress markers were taken 8 a.m one day prior to surgery , half an hour after initiation of pneumoperitoneum and one hour after the end of surgery.	—

Measure

Time frame

1. To determine the efficacy of intrathecal morphine for perioperative analgesia in patients undergoing total laparoscopic hysterectomy by its effect on VAS. 2. To assess the effect of intrathecal morphine on perioperative endocrine stress markers compared with fentanyl infusion.Timepoint: 1.The first pain assessment was done as soon as the patient was awake, oriented and capable of following commands. VAS scoring was done 2-hourly for 8 hours and at 24 hours. 2.Blood samples for stress markers were taken 8 a.m one day prior to surgery , half an hour after initiation of pneumoperitoneum and one hour after the end of surgery.

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Secondary

Measure	Time frame
1. To assess perioperative opioid sparing effect of intrathecal morphineTimepoint: 24 hours	—

Countries

India

Contacts

Public ContactProfSRajeshwari

All India institute of medical sciences

drsrajeshwari@gmail.com9868397810

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026