Health Condition 1: null- ASA-I and ASA-II CLASS PATIENTS
Conditions
Interventions
Intervention1: Group D:: Dexmedetomidine loading dose infusion @ 1 mcg/kg over 10 min
then maintenance infusion initiated at 0.6 mcg/kg/hr and titrated to achieve desired clinical effect with dose ranging from 0.2-0.7mcg/kg.
Control Intervention1: Group P:: Propofol at loading dose of
then maintenance @ 1-3mg/kg/hr. Analgesia with fentanyl as 1-2 mcg/kg and anxiolytic midazolam as 0.01-0.05mg/kg bolus is given in every patient.
Sponsors
st stephens hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA class I-II patients. 2. Adults of age group in between 20-50 years. 3. Adults of body weight in range of 40-75 kgs. 4. Surgeries of duration 45 minutes.
Exclusion criteria
Exclusion criteria: Agitated uncooperative patients who refused to provide consent, Patients with history of any of drug allergy, hemodynamically unstable patients like hypotensive patient, cardiac patients with history of angina, conduction defects angioplasty, CABG, severely hypertensive patients, septicemic patients, pregnant women, children below 12 years of age and elderly patients of age above 60 years were excluded from study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of sedation (OAASâ?¤3) was comparable in both groups (p0.05). Rescue analgesia with fentanyl was needed in 30% patients of group D than in 17.63% patients of group P (p0.05). Level of arousal was faster and better in group D at 5min after procedure (p0.05). Hemodynamic were stable in group D as with group P patients (p0.005). Dry mouth reported by 3 patients.Timepoint: Degree of sedation (OAASâ?¤3) was comparable in both groups (p0.05). Rescue analgesia with fentanyl was needed in 30% patients of group D than in 17.63% patients of group P (p0.05). Level of arousal was faster and better in group D at 5min after procedure (p0.05). Hemodynamic were stable in group D as with group P patients (p0.005). Dry mouth reported by 3 patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Rescue analgesia with fentanyl was needed in 30% patients of group D than in 17.63% patients of group P (p0.05). Dry mouth reported by 3 patients.Timepoint: at the end of procedure. | — |
Countries
India
Contacts
Public ContactGAURAV SINGH TOMAR
st. stephens hospital
Outcome results
None listed