Health Condition 1: null- Steroid Sensitive Nephrotic Syndrome
Conditions
Interventions
Intervention1: Prednisolone: Prednisolone 2 mg/kg daily till remission followed by 1.5 mg/kg alternate day for 2 weeks for relapse
Control Intervention1: Prednisolone: Prednisolone 2 mg/kg daily till
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with steroid sensitive nephrotic syndrome 2. Currently in relapse 3. Those who give written informed consent
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with steroid resistant Nephrotic Syndrome 2. Patients with frequent relapses (defined as 2 or more relapses in 6 months or >3 in 12 months) or steroid dependence (defined as 2 consecutive relapses on alternate day therapy or within 2 weeks of discontinuation of therapy) 3. Known secondary cause (e.g. Hepatitis B, SLE, HSP) 4. Patients on alternate regimens with levamisole/cyclophospahmide/mycophenolate mofetil/azathioprine/rituximab 5. Patients who have not recieved atleast 4 weeks of daily steroids at 2 mg/kg followed by 4 weeks of 1.5 mg/kg alternate day steroids during initial episode
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of children becoming frequently relapsing nephrotic syndromeTimepoint: 0 and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time to first relpase 2. Relapse rates 3. Cumulative dose of steroids 4. Adverse effects of steroidsTimepoint: 0, 1 mo, 3 mo, 6 mo, 9 mo, 12 mo | — |
Countries
India
Contacts
Public ContactProf Pankaj Hari
All India Institute of Medical Sciences
Outcome results
None listed