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Can transiently raising breath volume to higher (normal) breath volume in patients on ventilator receiving low breath volume and by measuring blood pressure change will help to identify patients who will get benefited from giving fluids.

Can transiently increasing tidal volume to 8 ml/Kg PBW and measuring PPV improve the reliability of PPV in patients receiving low tidal volume ventilation?

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/11/006335
Enrollment
20
Registered
2015-11-02
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients Age18yrs Acute circulatory failure Deeply sedated/paralysed) With invasive cardiac output monitoring using PICCO/ Volume View

Interventions

Intervention1: tidal volume: End Expiratory Occlusion Test done for 15 seconds thrice/day/patient (Established intervention). Control Intervention1: There is no comparator agent: There is no comparato

Sponsors

Dr Sheila Nainan Myatra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Adult patients (Age > 18 yrs ) • Acute circulatory failure • Receiving protective lung ventilation • With invasive cardiac output monitoring using PICCO/ Volume View with Phillips Intel View monitor (MP700)

Exclusion criteria

Exclusion criteria: • Cardiac arrhythmias, IHD • Previously known significant valvular disease or intracardiac shunt • Air leakage through chest drains • An urgently required fluid challenge • Abdominal compartment syndrome, and pregnancy

Design outcomes

Primary

MeasureTime frame
To detect whether measuring PPV by transiently increasing tidal volume to 8ml/kg IBW in patients ventilated with low tidal volume, can reliably predict fluid responsiveness.Timepoint: 1 year

Secondary

MeasureTime frame
To detect whether EEOT is reliable in patients ventilated with 6 ml/kg IBW.Timepoint: 1 year

Countries

India

Contacts

Public ContactDr Natesh Prabu R

Tata Memorial Hospital

nateshchillsout@yahoo.com09969523803

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026