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A study to evaluate platelet rich plasma as a substance to facilitate easier removal of tumorous tissue from the intestine

A randomized controlled study to evaluate autologous platelet rich plasma as an ideal substance for submucosal injection during endoscopic mucosal resection

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/10/006325
Enrollment
90
Registered
2015-10-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with sessile gastrointestinal polyps of diameter 1mm-20mm diagnosed by Upper gastrointestinal endoscopy or colonoscopy.

Interventions

Intervention1: Sterile autologous platelet rich plasma: Platelet-rich plasma, contains a platelet concentration of at least 1,000,000 platelets/ µ L in 5 mL of plasma. It acts as a sub-mucosal cushi

Sponsors

Andhra Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with sessile gastrointestinal polyps of diameter 1mm to 20mm diagnosed by Upper gastrointestinal endoscopy or colonoscopy will be included for the study. 2. If multiple polyps are present, only the largest sessile polyp (but less than or equal to 20 mm diameter) will be considered for the study.

Exclusion criteria

Exclusion criteria: 1. Age less than 20 years and age greater than 80 years 2. Pedunculated polyps 3. Sessile polyps less than 1 mm or greater than 20 mm in diameter 4. Lesions with ulceration 5.Friability 6. Non- lifting sign or lesions demonstrating deep submucosal invasion 7. Residual or recurrent lesion 8. Diagnosed case of inflammatory bowel disease 9. Coagulopathies 10. Cardiac pacemaker 11. Pregnant or lactating females 12. Patients who are on anti-coagulant drugs and anti-platelet drugs 13. Routine contraindications for gastrointestinal endoscopy

Design outcomes

Primary

MeasureTime frame
To measure the en-bloc resection rate of gastrointestinal polyps in all the included study participants En-bloc resection rates will be compared between the two study arms using percentages and proportions. Parametric and non-parametric data will be analyzed with suitable tests of significance.Timepoint: After the endoscopic procedure is completed—

Secondary

MeasureTime frame
To identify any post-procedural complications of ENdoscopic Mucosal Resection (EMR)Timepoint: a. Immediately after EMR b. After two weeks during a follow-up endoscopy or colonoscopy—

Countries

India

Contacts

Public ContactPalakurthy Murali Krishna

Andhra Medical College

muralikrishna63@yahoo.com9032032000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026