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A study of the levels of the enzyme glutathione-s-transferase in patients receiving intravenous paracetamol during and after surgery

Study of glutathione-s-transferase levels in patients receiving intravenous paracetamol perioperatively - a randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/10/006307
Enrollment
60
Registered
2015-10-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA Physical status 1 and 2 undergoing laparoscopic gastro-intestinal surgeries

Interventions

Intervention1: Paracetamol infusion group: Patients would receive 100 ml infusion of 1 gram of paracetamol following induction of anethesia, and followed up with similar infusions every 8 hours upto 2

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status 1 and 2 undergoing laparoscopic gastro-intestinal surgeries

Exclusion criteria

Exclusion criteria: patients with obesity(body weight > 20% of ideal body weight) excessive alcohol intake previous liver disease pregnancy renal failure any exposure to general anesthesia with inhalational anesthetics within 3 months

Design outcomes

Primary

MeasureTime frame
To measure plasma gluatathione-s-transferase levelsTimepoint: pre-operatively, At 1 hour, 6 hours and 24 hours after induction of anesthesia—

Secondary

MeasureTime frame
To measure plasma AST, ALT, albumin and globulinTimepoint: pre-operatively and postoperatiely after 24 hours—

Countries

India

Contacts

Public ContactSATYEN PARIDA

JIPMER

jipmersatyen@gmail.com9940973502

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026