A clinical trial to study the effects of three drugs, Mephentermine, Ephedrine and Phenylephrine on Post Subarachnoid Block Hypotension during Lower Segment Caesarean Section (LSCS).

â??Evaluation of Safety and Efficacy of Mephentermine, Ephedrine and Phenylephrine on Post Subarachnoid Block Hypotension during Lower Segment Caesarean Section (LSCS): A Randomized, Prospective, Parallal Group, Double Blind Clinical Trial.â??

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/10/006255

Enrollment

150

Registered

2015-10-13

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Pregnant women

Interventions

Intervention1: Injection Ephedrine: Bolus dose 10 mg given intravenously immediately after subarachnoid block Maintenance dose of 5 mg given whenever there is episode of hypotension. Intervention2: In

Eligibility

Inclusion criteria

Inclusion criteria: - ASA 1 or 2 women with term, uncomplicated, singleton pregnancy scheduled to undergo elective and emergency caesarean section - Systolic blood pressure: 100 to 150 mm of Hg - Diastolic blood pressure: 70 to 90 mm of Hg

Exclusion criteria

Exclusion criteria: - Patient refusal to participate in study - Absolute and relative contraindication to spinal anesthesia - Pregnancy induced hypertension, pre-eclampsia, eclampsia etc.. - CVS (e.g. valvular heart disease) and CNS(e.g. cv stroke) abnormalities - Diabetes Mellitus (Random blood sugar >140 mg/dl) - Fetal (e.g. macrocephaly) and placental abnormalities(e.g. placenta previa) - Sensitivity to local anaesthetic agent used in study

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of I.V. bolus mephentermine, ephedrine and phenylephrine for maintenance of blood pressure following spinal anaesthesia for elective as well as emergency caesarean section. Timepoint: Immediately after subarachnoid block and during LSCS whenever episode of hypotension.	—

Secondary

Measure	Time frame
To compare the effects and safety of mephentermine, ephedrine and phenylephrine, administered intravenously, on maintenance of blood pressure before delivery of baby and fetal outcome in pregnant women. Timepoint: Immediately after subarachnoid block and during LSCS whenever episode of hypotension.	—

Countries

India

Contacts

Public ContactDr C B Tripathi

Govt. Medical College, Bhavnagar.

cbrtripathi@yahoo.co.in09825951678

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026