Health Condition 1: null- Effects of Isoflurane and Desflurane on Cognitive Dysfunction following anaesthesia
Conditions
Interventions
Intervention1: Desflurane: Relatively newer inhalational anaesthetic agent now being increasingly used for neurosurgeries due to its properties of rapid emergence. Many studies have
demonstrated neuro
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Patients scheduled for minimally invasive surgery under general anaesthesia Age between 18-65 years American Society of Anaesthesiologists (ASA) Grade I and II patients Patients with Glasgow Coma Scale (GCS) of 15
Exclusion criteria
Exclusion criteria: Cardiorespiratory disorders Associated cerebral disease Psychiatric illness Preoperative cognitive disorders Electrolyte and hormonal imbalance Second operation. Low level of education History of drug abuse Postoperative meningitis Administration of high dose steroids
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome variables will be a) Cognitive function at three months following anaesthesia b) Estimation of serological biomarkers of cognitive dysfunction. Timepoint: Cognitive function 1) At three months postoperative Estimation of serological biomarkers 1)preoperative 2) postoperative after one hour following anaesthesia 3) postoperative at one week | — |
Primary
| Measure | Time frame |
|---|---|
| The primary outcome variable will be assessment of cognitive function at one week following anaesthesia. The cognitive functions will be assessed preoperatively and compared with cognitive functions at one week following anaesthesia.Timepoint: Psychological tests for evaluating cognitive functions 1)preoperative 2) postoperative at one week | — |
Countries
India
Contacts
Public ContactDr Hemant Bhagat
Post Graduate Institute of Medical Education and Research
Outcome results
None listed