Health Condition 1: null- Female infertility
Conditions
Interventions
Intervention1: Antitubercular treatment: 2 months INTENSIVE PHASE with
Rifampicin (600 mg daily, given orally for 2 months), Isoniazid (300 mg daily, given orally for 2 months), ethambutol (1200 mg d
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: The inclusion criteria included women who were in the reproductive age group (20-40 years) with primary or secondary infertility and cohabiting with their husbands. Patients with positive endometrial DNA-PCR, with patent tubes on laparoscopy and all other tests (EA-HPE, AFB, Laparoscopy) being negative for genital TB were included in the study. Patients above the age of 40 years with symptoms suggestive of genital TB except infertility and HSG suspicious of genital TB due to extravasation or calcification or genital TB diagnosed on basis of EA-histopathology, AFB smear, hysteroscopy and laparoscopic findings were excluded from the study. Patients were randomized by block randomization into two groups: Group I where patients received ATT for 6 months was given and Group II where patients were not given ATT. A total of 100 infertile women (50 in each group), as per inclusion/exclusion criteria were recruited.
Exclusion criteria
Exclusion criteria: − Age >40 years − Symptoms suggestive of Genital TB except infertility − HSG suspicious of genital TB due to extravasation or calcification − Genital TB diagnosed on basis of EA-histopathology, AFB smear, Bactec culture, hysteroscopy and laparoscopic findings
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The patients in the two groups will be compared for their Reproductive outcome (conception during 12 months post laparoscopy) Timepoint: 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| PCR negativity after 6 months in two groups(with ATT vs. no ATT)Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactAlka Kriplani
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed