Health Condition 1: null- Cancer patients posted for ovarian cancer surgery
Conditions
Interventions
Intervention1: Palonosetron and dexamethasone: Palonosetron (0.075 mg) and dexamethasone (4mg) will be given in operation theatre at the time of wound closer and there after placebo drug will be given
Sponsors
Nil
Eligibility
Inclusion criteria
Inclusion criteria: 18-70 years old female patients, American Society of Anaesthesiologist class I and II, Post chemotherapy patients undergoing open ovarian cancer surgery and requiring opioid based patient controlled analgesia
Exclusion criteria
Exclusion criteria: 1. American Society of Anaesthesiologist class III and above, 2. Smokers 3. Cognitive impairment or an active psychiatric condition 4. Patients with known liver and kidney diseases, 5. History of a palanosetron/ ondansetron/ dexamethasone or fentanyl allergy 6. Use of corticosteroids, psychoactive drugs or any other medication with known emetic or antiemetic effect within 24 hrs prior to surgery 7. History of opioid abuse. Extended Exclusion Criteri 1. Patients who will be shifted to intensive care unit on endotracheal tube for post operative mechanical ventilation
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Comparison ofintensities of nausea, pain, cumulative dose of opioid, rescue analgesics and antiemetic requirements, discontinuation of opioid ahead of time, and adverse eventsTimepoint: Every half an hour for first 2 hours and after that at intervals of 2 to 6, 6 to 24, 24 to 48 hours postoperatively. | — |
Primary
| Measure | Time frame |
|---|---|
| The overall incidence of Post Operative Nausea and Vomiting between the Ondasetron with dexamethasone and Palonosetron with dexamathasone groups.Timepoint: Every half an hour for first 2 hours and after that at intervals of 2 to 6, 6 to 24, 24 to 48 hours postoperatively. | — |
Countries
India
Contacts
Public ContactDr Amit Kumar
Tata Memorial Hospital, Parel, Mumbai (India)
Outcome results
None listed