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A study to Compare the effectiveness of packing nose with two different pain relieving medicines in preventing the rise in heart rate and blood pressure during the surgical procedure and reducing pain after surgery in endoscopic surgical removal of pituitary tumors through nose.

Comparison of the effect of topical intranasal 1.5% lignocaine and 0.5% Levobupivacaine on hemodynamic response and postoperative analgesia in Endoscopic Binostril transnasal transsphenoidal resection of pituitary tumors

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/09/006216
Enrollment
100
Registered
2015-09-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Pituitary Adenoma

Interventions

Intervention1: LEVOBUPIVACAINE 0.5%: 15 ml 75mg Levobupivacaine, Intranasal packing for 10 minutes once before surgery Control Intervention1: LIGNOCAINE 1.5%: 15 ml 225mg Lignocaine Intranasal packing

Sponsors

Christian Medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: consenting patients, ASA physical status class 1-3

Exclusion criteria

Exclusion criteria: non consenting patients, previous nasal surgeries, pregnanat woman, age less than 18 or more than 65, ASA physical status class 4 or 5, known allergies to Local anaesthetic drug, known seizure disorder patients, known cardiac arrythmia patients

Design outcomes

Primary

MeasureTime frame
Attenuation of hemodynamic response to surgical stimulus in binostril Transnasal Transsphenoidal pituitary surgeriesTimepoint: At insertion of endoscope, 3 min after insertion of endoscope, At incision, 1,2,3,4,5,10,20,30,40,50,60,90,120 minutes after incision—

Secondary

MeasureTime frame
post operative pain reliefTimepoint: within 24 hour post operative period—

Countries

India

Contacts

Public ContactDr Georgene Singh

Christian Medical College

georgene@cmcvellore.ac.in9443292504

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026