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The trend of rise and fall of circulating DNA after the first cycle of chemotherapy in breast cancer patients

The dynamics of circulating DNA and nucleosomes following adjuvant, neoadjuvant or palliative chemotherapy for early breast cancer (EBC), locally advanced breast cancer (LABC) and metastatic breast cancer (MBC)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2015/09/006195
Enrollment
22
Registered
2015-09-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients with breast cancer receiving chemotherapy

Interventions

Intervention1: chemotherapy: Chemotherapy (ar per the treating doctor) will be administered to breast cancer patients and following that the dynamics of DNA and nucleosomes will be studied

Sponsors

Tata Memorial Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with histopathologically confirmed breast cancer 2. Patients with early, locally advanced or metastatic breast cancer who are planned for some type of chemotherapy. 3. Patients who are willing to participate in the study including blood sampling at the defined time points EXCLUSION CRITERIA:patients with diabetes and autoimmune disorders

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
1. The median and the mean days to peak DNA and nucleosome levels in all patients and in LABC/MBC and OBC (post-operative) groups. Timepoint: : 6 hours, 24hours, 48hours (3rd day), 72hours (4th day), 96hours (5th day), 144hours (7th day) and 312hours (14th day).—

Secondary

MeasureTime frame
2. The development of anaemia, grade IV neutropenia and/or thrombocy-topenia with the DNA and nucleosome levelsTimepoint: : 6 hours, 24hours, 48hours (3rd day), 72hours (4th day), 96hours (5th day), 144hours (7th day) and 312hours (14th day).—

Countries

India

Contacts

Public ContactDrSudeep Gupta

Tata Memorial Hospital

sudeepgupta04@yahoo.com02224177201

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026