To study the effect of licorice on patients with gene polymorphism

11 beta HSD-1 gene polymorphism in patients with type 2 diabetes, metabolic syndrome and PCOS- Effect of carbenoxolone (Licorice) on anthropometric and metabolic parameters of patients with this polymorphism

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/09/006171

Enrollment

Registered

2015-09-09

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Type 2 diabetics, metabolic syndrome and polycystic ovary syndrome subjects showing 11 beta HSD-1 gene polymorphism

Interventions

Intervention1: Licorice: orally administer 250 mg licorice, four times daily for 3 weeks. Control Intervention1: Placebo: orally administer 250 mg placebo, four times daily for 3 weeks.

Eligibility

Inclusion criteria

Inclusion criteria: Patients who sign informed consent Type 2 diabetics confirmed by ADA criteria Metabolic syndrome subjects confirmed by IDF criteria Polycystic ovary syndrome subjects confirmed by rotterdam criteria

Exclusion criteria

Exclusion criteria: Type 1 diabetes Diabetics on insulin Subjects with HbA1C >9.5%, FBS >200 mg/dl, BP >160/100,eGFR >30% Known hypokalemia Oedema Women of child bearing potential Currently on alcohol abuse

Design outcomes

Primary

Measure	Time frame
1.Change from baseline FBS, PPBS and fructosamine. 2.Proportion of patients who maintain good short term glycemic control without the need of additional antidiabetic medication. 3.Change from baseline weight, waist circumference 4.Change from baseline in total cholesterol, LDL, HDL, triglycerideTimepoint: 3 weeks	—

Secondary

Measure	Time frame
Proportion of patients who show hypokalemia, oedema, elevation of blood pressure of 5 mmHg or more and other side effectsTimepoint: Baseline and every week upto 3 weeks	—

Countries

India

Contacts

Public ContactDr Prabha Adhikari

Kasturba Medical college, Mangalore, Manipal university, Karnataka

prabha.raghuveer@gmail.com9880991290

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026