Health Condition 1: null- Children aged 1 month to 12-years with Suspected or confirmed sepsis AND evidence of systemic inflammatory response syndrome (SIRS)AND Evidence of either refractory hypotension OR hypoperfusion.
Conditions
Interventions
Intervention1: Early Goal Directed Therapy: The EGDT protocol adapted from Rivers et al, will be commenced by the study team within 1 hour of enrolment.
Control Intervention1: standard care: The stand
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Suspected or confirmed sepsis AND presence of the evidence of systemic inflammatory response syndrome (SIRS) criteria AND Evidence of either refractory hypotension OR hypoperfusion.
Exclusion criteria
Exclusion criteria: 1. Contraindication to central venous catheter (CVC) insertion like active clinical bleeding and local site infections etc. 2. Primary cardiac illness. 3. Severe malnutrition. 4. Patient referred to JIPMER with in-situ internal/subclavian central line/resuscitated or stay more than 6 hours for septic shock management.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all-cause mortality in children with septic shock.Timepoint: all-cause mortality in children with septic shock at 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the length of PICU and hospital stayTimepoint: at 28 days;To compare the number of new organ dysfunctions at 24 hours and during PICU stay (SOFA, PeLOD Score).Timepoint: at 24 hours and PICU stay;To compare the proportion of patients achieved predetermined therapeutic endpoint and time taken to achieve predetermined therapeutic endpoints at 6 hours and during PICU stay.Timepoint: at 6 hours and PICU stay.;To compare the use and duration of organ support (Mechanical ventilation, vasoactive support and renal replacement therapy).Timepoint: PICU stay | — |
Countries
India
Contacts
Public ContactDr Ramesh Kumar R
JIPMER
Outcome results
None listed