Health Condition 1: N189- Chronic kidney disease, unspecified
Conditions
Interventions
Intervention1: sodium bicarbonate: Sodium bicarbonate tablets 500 mg tablets given orally . Starting dose 500 mg three times a day
dose will be titrated weekly to keep venous bicrabonete levels between 24-26 meq/l.
Once the target dose is attained , patient will be maintained on the same dose for 6 months
Control Intervention1
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: •Venous HCO3 less than 22 mEq/dl •Renal Function: 15 ml/min/1.73m2 - 59 ml/min/1.73m2(Both values inclusive) •Stable renal function for at least one month (less than 5 % fluctuations in GFR).
Exclusion criteria
Exclusion criteria: •Patients who had received bicarbonate therapy for more than two weeks duration in the preceding 6 months •Patients on hemodialysis •Structural and functional anomalies of Gastrointestinal tract •Decompensated chronic liver disease •Malignancy •Morbid obesity (BMI >40 kg/m2), •Immunosuppressive therapy of any kind •Uncontrolled diabetes mellitus (FBS > 250 mg/dl) •Overt congestive heart failure •Presence of chronic infections •HIV infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in nutrtitional status (assessed by anthropometric parameters, albumin,cholestrol and body fat percentage 2. Change in inflammatory biomarkers (IL-1β & TNF-α) Timepoint: At enrollment Six months post enrollment | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in glomerular filtration rateTimepoint: 6 months | — |
Countries
India
Contacts
Public ContactPriyamvada P S
JIPMER
Outcome results
None listed