Effect of anaesthesia administration to keep eye in central position during eye examination in children

Evaluation of minimum alveolar concentration (MAC) of sevoflurane and bispectral index (BIS) for maintenance of central eye position during short ophthalmic procedure in spontaneous breathing children under general anaesthesia and correlation of MAC of sevoflurane with BIS

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/08/006125

Enrollment

100

Registered

2015-08-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- with eye diseases

Interventions

Intervention1: sevoflurane: it is an inhalational agent which has low solubility index and facilitate rapid recovery and is useful in adjustment of depth os anaesthesia. Control Intervention1: Bi-spec

Eligibility

Inclusion criteria

Inclusion criteria: All children, 1-8yrs undergoing short ophthalmic procedure under general anaesthesia

Exclusion criteria

Exclusion criteria: a. Significant deviation of eye b. Any known CNS pathology especially seizure disorder, cerebral palsy c. Any known cardiovascular, pulmonary, genetic disorder d. anticipated difficult airway e. Parental refusal to participate f. Allergy to proparacaine

Design outcomes

Primary

Measure	Time frame
1. To estimate the minimum alveolar concentration (MAC) of sevoflurane to maintain central eye position for ophthalmic procedures in spontaneous breathing children under general anaesthesia 2.To estimate the bi-spectral index (BIS) to maintain central eye position for ophthalmic procedures in spontaneous breathing children under general anaesthesiaTimepoint: from the time of intravenous cannulation till the end of eye examination	—

Measure

Time frame

1. To estimate the minimum alveolar concentration (MAC) of sevoflurane to maintain central eye position for ophthalmic procedures in spontaneous breathing children under general anaesthesia 2.To estimate the bi-spectral index (BIS) to maintain central eye position for ophthalmic procedures in spontaneous breathing children under general anaesthesiaTimepoint: from the time of intravenous cannulation till the end of eye examination

—

Secondary

Measure	Time frame
To evaluate the correlation between MAC of sevoflurane and BIS to maintain central eye position for short ophthalmic procedures during spontaneous breathing children under general anaesthesiaTimepoint: from the time of intravenous cannulation till the end of eye examination	—

Countries

India

Contacts

Public ContactRenu Sinha

All India Institute of Medical Sciences

renuagarwal4@rediffmail.com9868397822

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026