Effectiveness of reduction of WBCs in blood bags prepared at cold temperature in comparison to those prepared at room temperature.

Pre-storage leukodepletion of red cells at 4 degree Celsius and at room temperature: comparison of efficacy and clinical impact following transfusion.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/08/006116

Enrollment

19198

Registered

2015-08-19

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T808- Other complications following infusion, transfusion and therapeutic injection Health Condition 2: null- Reduction in incidence of febrile non hemolytic transfusion reaction after transfusion of LDRC bags processed at 4 degree Celsius in comparison to those processed at 22 degree Celsius

Interventions

Intervention1: Transfusion of LDRC blood bags to patients (in need), processed at either 4 or 22 degree Celsius for 6 months each.: These LDRC blood bags (prepared at either 4 or 22 degree Celsius) wi

Eligibility

Inclusion criteria

Inclusion criteria: Patients, of any age and gender, requiring Leukodepleted red cell blood bags (LDRCs) are alloted the same, these mainly constitute nephrology and cardiothoracic surgery patients. The decision to transfuse LDRC blood bag to a patient is mainly dependent on the decision of the clinician/treating doctor or blood bank medical officer towards the benefit of the patient, and also on the availability of LDRC bags in blood bank.

Exclusion criteria

Exclusion criteria: •Patients on antipyretic medication. •Patients with co-existing febrile illness.

Design outcomes

Primary

Measure	Time frame
Mean reduction in number of residual WBCs achieved in LDRC bags processed at 4 degree Celsius as compared to 22 degree Celsius.Timepoint: 4 weeks	—

Secondary

Measure	Time frame
Incidence of febrile non haemolytic transfusion reactions in patients transfused with LDRC bags processed at 4 degree Celsius in comparison to those processed at 22 degree Celsius.Timepoint: 32 months	—

Countries

India

Contacts

Public ContactDr Siddharth Mittal

Christian Medical College and Hospital, Vellore

purna@cmcvellore.ac.in9442668499

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026