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A study comparing two drugs fentanyl and dexmedetomidine in decreasing airway and circulatory reflexes during patient coming out of anaesthesia and extubation

Comparison of fentanyl with dexmedetomidine in attenuating airway and circulatory reflexes during emergence and extubation: a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/08/006112
Enrollment
60
Registered
2015-08-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA PHYSICAL STATUS 1/2

Interventions

Intervention1: DEXMEDETOMIDINE: Dexmedetomedine 0.75mcg per kg given over 10 minutes given 5 minutes before giving neostigmine Control Intervention1: FENTANYL: Fentanyl given 1mcg per kg 5 minutes bef

Sponsors

no
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Willingness • ASA 1 & 2 physical status

Exclusion criteria

Exclusion criteria: 1. Active upper respiratory tract infection 2. Who require intraoperative nasogastric tube

Design outcomes

Primary

MeasureTime frame
airway reflexes before extubation smoothness of extubationTimepoint: 1.airway reflexes are assessed just before extubation 2.Smoothness is assessed during extubation—

Secondary

MeasureTime frame
Mean arterial pressureTimepoint: 2 mins interval from study drug administration to 15 mins after extubation—

Countries

India

Contacts

Public ContactDR RANIP

MAHATMA GANDHI MEDICAL COLLEGE AND RESEARCH INSTITUTE

anaesrani@gmail.com09443116908

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026