Health Condition 1: null- head injury
Conditions
Interventions
Intervention1: erythromycin and metoclopramide group: erythromycin group will receive Crushed tablet erythromycin 250 mg through RT every 8 hrly for 3 days. Metoclopramide group will receive crushed t
Sponsors
Post Graduate Institue of Medical education research
Eligibility
Inclusion criteria
Inclusion criteria: -Age >= 18 years of age of either gender -Admission to trauma ICU within 72 hours of head injury -GCS >= 5
Exclusion criteria
Exclusion criteria: •Patient with blunt trauma abdomen. •Severe thoracic injury with associated hemothorax. •Allergy to macrolide or metoclopramide. •Patient taking erythromycin or metoclopramide or drugs that interact with them such as carbamazepinem digoxin, cyclosporein, fluconazole etc. •Malabsorptive gastrointestinal diseases (obstruction, perforation, short bowel syndrome, or Crohnâ??s disease) •Abnormal liver function (defined by the presence of 2 of the following: transaminases -3 times the upper limit of normal or total bilirubin -3 times the upper limit of normal, or prothrombin time -2 times the upper limit of normal). •Renal dysfunction requiring active renal replacement therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study will be the incidence of high GAV with the use of prokinetic drugsTimepoint: every 4 hrly for 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Any episode of diarrhea or abdominal distensionTimepoint: every 4 hrly for 5 days;daily gastric volume emptiedTimepoint: daily for 5 days;Enteral Feeding failureTimepoint: every 4 hrly for 5 days;percentage of target calorie requirement metTimepoint: daily for 5 days | — |
Countries
India
Contacts
Public ContactJeetinder Makkar
POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH, CHANDIGARH
Outcome results
None listed