Health Condition 1: L00-L99- Diseases of the skin and subcutaneous tissue Health Condition 2: null- Oral Submucous Fibrosis
Conditions
Interventions
Intervention1: injection Dexamethasone and
tablet Curcumin: Intralesional dexamethasone sodium phosphate 4mg/ml injection biweekly and tablet Turmix(Curcumin & Piperine tablet) 300mg thrice daily ora
Sponsors
Dr Nilima Sharma
Sanat Products Limited
Eligibility
Inclusion criteria
Inclusion criteria: Patients of either sex above 20 years of age. A positive history of chewing arecanut or one of its commercial preparations. Diagnosis of OSMF was made on the basis of natural history and characteristic clinical features which included the presence of burning sensation in the mouth, intolerance to spicy food, blanching and loss of suppleness of oral mucosa, presence of palpable fibrous bands and decreased mouth opening.
Exclusion criteria
Exclusion criteria: Patients with chronic illnesses and systemic diseases(diabetes, hypertension, liver disorders, kidney disorders, autoimmune disorders), other mucosal lesions. Pregnant and lactating women. Patients with a known allergy or contraindication to the study drugs. Malignancy Temporomandibular joint arthrosis , Fracture mandible ramus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the efficacy of curcumin as an antioxidant adjuvant to corticosteroid injections in the management of oral submucous fibrosis.Timepoint: Every month | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Resumption of normal eating, chewing and speech. 2. Change or improvement in maximal jaw opening, measuredas the interincisal distance. 3. Reduction in fibrosis evaluated by pre and post treatment ultrasonography. 4. Change in severity of oral/mucosal burning pain using Visual Analogue Scale validated pain scale. Timepoint: every 4 days for 3 months | — |
Countries
India
Contacts
Public ContactDrNilima Sharma
Hamdard Institute of Medical Sciences and Research
Outcome results
None listed