Health Condition 1: null- Bacterial meningitis
Conditions
Interventions
Intervention1: Rifampicin single dose before Ceftriaxone: Rifampicin 20 mg/kg was administered orally to one group of children with suspected bacterial meningitis 30 minutes prior to ceftriaxone and 2
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: Patients with clinical features of bacterial meningitis in the form of acute onset of fever ( And Laboratory criteria (Any one of the following) o Positive CSF or Latex Agglutination Test (LAT) for H.influenzae, S.pneumoniae, and N.meningitidis o >10 WBC/ml of CSF, with blood culture positive for any bacteria o >100 WBC/ml with >50% polymorphonuclear cells and CSF glucose o >1000 WBC/ml of CSF with >75% polymorphonuclear cells
Exclusion criteria
Exclusion criteria: Patients with features of raised ICP Previously received antibiotics > 24 hours , Developmental delay, Severe malnutrition Previously documented immunodeficiency Infected lumbar puncture site
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the levels of TNF alpha, S 100 B and NSE in children with bacterial meningitis recieving single dose Rifampicin before ceftriaxone, with those recieving ceftriaxone aloneTimepoint: day 1 and day 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| Hearing assesment in both groups of childrenTimepoint: 3 months post discharge;To examine the neurological outcome in both the groups of childrenTimepoint: At discharge and at 3 months post discharge;To measure the levels of TNF alpha and IL 6 in serum of children with bacterial meningitis, recieving single dose Rifampicin before ceftriaxone, with those recieving ceftriaxone aloneTimepoint: day 1 and day 5 | — |
Countries
India
Contacts
Public ContactProf Sunit Singhi
Post graduate Institute of Medical Education and Research,
Outcome results
None listed