How Much Does Epidural Analgesia Influence General Anaesthesia?

QUANTIFICATION OF INFLUENCE OF EPIDURAL ANALGESIA ON ENTROPY GUIDED GENERAL ANAESTHESIA USING SEVOFLURANE â?? A RANDOMIZED CONTROLLED TRIAL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/06/005949

Enrollment

Registered

2015-06-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Inhalational Agent consumption

Interventions

Intervention1: Bupivacaine: Bupivacaine 0.25% given through continuous epidural infusion at 10ml/hour till the end of surgery Control Intervention1: Normal Saline: Normal Saline 0.9% given through con

Eligibility

Inclusion criteria

Inclusion criteria: Elective laparotomy, ASA I & II

Exclusion criteria

Exclusion criteria: History of substance abuse, major spine abnormalities, difficult airway, coagulation abnormalities and those on anti-convulsants or anti-depressants were excluded. Emergency laparotomies and patients with history of allergy to local anaesthetics

Design outcomes

Primary

Measure	Time frame
Percentage reduction of end tidal concentration of Sevoflurane when GA is combined with Epidural analgesiaTimepoint: Outcome assessed at the end of study	—

Secondary

Measure	Time frame
To compare and quantify the difference in end tidal Sevoflurane requirement between the twoTimepoint: Assessed at the end of the study	—

Countries

India

Contacts

Public ContactDalena Mathew

Mahatma Gandhi Medical College & Research Institute

rshankarm@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026