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Association of swelling and pain indicators in knee joint with bone tunnel widening and after surgery results in patients for treatment of knee ligament (anterior cruciate) injury.

Association of synovial fluid levels of interlukin-1, 6 and tumor necrosis factor-α with tunnel widening and clinical outcome in patients undergoing arthroscopic anterior cruciate ligament reconstruction.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2015/06/005947
Enrollment
50
Registered
2015-06-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S835- Sprain of cruciate ligament of knee

Interventions

None listed

Sponsors

GMCH sector
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male patients below the age of 40 years with skeletal maturity. 2. ACL injury diagnosed clinically and radiologically. 3. Informed consent given and willing to participate.

Exclusion criteria

Exclusion criteria: 1. Female patients. 2. Skeletally immature patients. 3. Age above 40 years. 4. Concomitant injury to other ligaments. 5. Time since injury is not known or not sure. 6. Injury or past history of knee pain suggestive of possible OA on either side. 7. Injury during non-sports related activities. 8. Inflammatory arthritis including RA, AS, ReA. 9. Systemic inflammatory disorders and gouty arthritis. 10. Autoimmune disorders. 11. Subjects on steroids or other long term anti-inflammatory medication. 12. Crystal arthropathy or diabetes mellitus. 13. Recent or past infection of knee joint or its adjoining area. 14. Ongoing or recent infection which can alter levels of serum CRP including URTI, UTI etc. 15. Any Malignancy.

Design outcomes

Secondary

MeasureTime frame
To measure the synovial fluid levels intelukin-1, interlukin-6, TNF-α in patients undergoing ACL reconstruction.Timepoint: 1 year and 6 months;To measure anterior laxity, clinical outcome using Lysholm and Tegner Scale in ACL reconstructed knees and ascertain its association with initial levels of inflammatory markers at 1 year follow-up.Timepoint: 1 year and 6 months—

Primary

MeasureTime frame
To explore the association between synovial fluid levels of intelukin-1, interlukin-6 and TNF-α perioperatively with tunnel widening after ACL reconstruction.Timepoint: 1 year and 6 months—

Countries

India

Contacts

Public ContactSourabh khatri

Government Medical College and Hospital, Sector 32 Chandigarh

sourabhkk@gmail.com9646121592

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026