Health Condition 1: null- Axillary hyperhidrosis
Conditions
Interventions
Intervention1: Surgical curettage
: Sub cutaneous curettage of sweat glands under tumescent anesthesia once and follow up for 6 months
Control Intervention1: Botulinum toxin injection: 50 units per ax
Sponsors
Indian Academy of Dermatology Venereology and Leprosy
Eligibility
Inclusion criteria
Inclusion criteria: •18 to 75 years •Persistent bilateral primary axillary hyperhidrosis •Gravimetrically minimal 50 mg spontaneous sweat production in each axilla, measured during 5 minutes in room temperature in calm condition •signed informed consent
Exclusion criteria
Exclusion criteria: • Medical condition that can be dangerous by treatment with Botulinum toxin, including myastenia gravis, Lambert-Eaton syndrome and each other disease that can interfere with the neuromuscular function • Secondary hyperhidrosis • Known allergy against study medication • Use of aminoglycosides, curare-like products, or other products which can interfere with the neuromuscular function
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiviness based on reduction in sweat production measured by gravimetry and duration of effect of both treatmentsTimepoint: Follow up assessments: 3 months, 6 months and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Subject satisfaction based on reduction in mean score on the Hyperhidrosis Disease Severity Scale (HDSS). Adverse events of both treatments Timepoint: Follow up assessments: 3 months, 6 months and 12 months | — |
Countries
India
Contacts
Public ContactDrEswariL
BMCRI
Outcome results
None listed