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efficacy of simvastatin gel local drug delivery in the management of gum diseases

THE COMPARITIVE EFFECT OF IN-SITU APPLICATION OF SIMVASTATIN GEL WITH PRF AND PRF ALONE IN THE SURGICAL MANAGEMENT OF OSSEOUS DEFECTS IN CHRONIC PERIODONTITIS-A QUASI EXPERIMENTAL STUDY

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/06/005910
Enrollment
30
Registered
2015-06-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- CHRONIC PERIODONTITIS

Interventions

Intervention1: SIMVASTATIN: IT IS A CHOLESTROL LOWERING DRUG WIDELY USED.HAVING ASECINDERY PROPERTY OF BONE FORMATION.SIMVASTATIN USED IN THE FORM OF GEL. Carbopol 934 P containing 1.2 m

Sponsors

ANU R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Systemically healthy patient diagnosed with generalised or localized (more than two sites) chronic periodontitis with bilateral intrabony defects • Clinical probing pocket depth >= 5 mm in 2 sites . • Radiographic evidence of bilateral intrabony defects in any 2 region

Exclusion criteria

Exclusion criteria: • History of antibiotics in last 2 months • History of periodontal therapy in last 6 months • Suspected allergy to statin group • Patients on systemic statin therapy • Aggressive periodontitis • Tooth with grade 3 mobility • Current smokers • Immunocompromised patient • Pregnant and lactating females • Blood disorders • Any other contraindication for periodontal surgery • Patients indicated for multiple extractions/undergone multiple extractions • Diabetes • Any systemic disorders. • Patients with dental infections like chronic periapical lesions,Apthous stomatitis,Oral lichenplanus

Design outcomes

Primary

MeasureTime frame
Plaque index probing pocket depth clinical attachment level RecessionTimepoint: Plaque index probing pocket depth clinical attachment level Recession

Secondary

MeasureTime frame
: radiographic evaluation of bone fillTimepoint: : radiographic evaluation of bone fill

Countries

India

Contacts

Public ContactANU R

Kerala University of Health Sciences

sebapazhoor@pazhoor.com9446482871

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026