Health Condition 1: null- PRE-DIABETICS with HYPERTENSION
Conditions
Interventions
Intervention1: Angiotensin Converting Enzyme Inhibitors
: 1. Ramipril 5 mg once daily for 3 months
2. Enalapril 5 mg once daily for 3 months
3. Enalapril 5 mg twice daily for 3 months
4. Enalapril 10
Sponsors
MAMATA GENERAL HOSPITAL
Eligibility
Inclusion criteria
Inclusion criteria: • Age >= 18 years and • Systolic blood pressure >= 140 and/or diastolic blood pressure >= 90 mmHg, • Patients on monotherapy of ACE-inhibitors / Angiotensin II-receptor blockers for the control of their blood pressure. • Impaired glucose tolerance with blood glucose levels between 140 â?? 200 mg/dl in oral Glucose Tolerance Test (Oral GTT)
Exclusion criteria
Exclusion criteria: • Previous or current antidiabetic medications • Patients with higher blood glucose levels > 200mg/dl, with overt diabetes • "Brittle" pre-diabetic patients in whom the physician anticipates to initiate antidiabetic medications within next 6 months • Hypertensive patients in whom the physician anticipates to start polytherapy within next 6 months • Female patients who are pregnant or nursing or planning pregnancy within the duration of the study • Suspected or known secondary cause of hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of ACE Inhibitors /ARBs on blood glucose level in hypertensive pre- diabetic patients by periodic Glucose Tolerance Test (GTT).Timepoint: 1 BASELINE 2 SIX MONTHS 3 TWELVE MONTHS | — |
Secondary
| Measure | Time frame |
|---|---|
| The exclusive role of RAS blockade, if any, in relation to other contributing factors such as Age, Sex, BMI, Blood pressure which may have confounding effect on the outcome.Timepoint: 1 BASELINE 2 SIX MONTHS 3 TWELVE MONTHS | — |
Countries
India
Contacts
Public ContactDr SOWMYA BONDALAPATI
MAMATA MEDICAL COLLEGE
Outcome results
None listed