Effect of dexmedetomidine on cerebral autoregulation during general anaesthesia

Effect of dexmedetomidine on cerebral autoregulation and CO2 reactivity during sevoflurane anaesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/06/005875

Enrollment

Registered

2015-06-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA I, UNDERGOING LUMBAR LAMINECTOMY WITH NO INTRACRANIAL PATHOLOGY

Interventions

Intervention1: dexmedetomidine/placebo: dexmedetomidine 1mcg/kg iv loading dose over 10 minutes followed by 0.5mcg/kg/hr iv infusion as maintenance dose(Group D) for rest of the surgery till 10 minute

Eligibility

Inclusion criteria

Inclusion criteria: adults aged 18-60 years who present for lumbosacral spine surgery.

Exclusion criteria

Exclusion criteria: 1. Refusal of consent 2. Pregnancy 3. Morbid obesity 4. Patients with comorbidities, ASA II and above , including cardiac rhythm abnormalities 5. Addictions(smoking/regular alcohol intake/IV drug abuse) 6. Drug intake(OCPs/SSRIs/TCAs/anticonvulsants/statins etc.) 7. Carotid disease/history of syncope/dizziness 8. Hyperlipidemia

Design outcomes

Primary

Measure	Time frame
1. to study the effect of dexmedetomidine as an anaesthetic adjuvant on cerebral autoregulation and CO2 reactivity using transcranial dopplerTimepoint: 5 mins after induction of anesthesia when BIS stable between 40-50.	—

Secondary

Measure	Time frame
1. effect of dexmedetomidine on intraoperative haemodynamic parameters during various stages of anaesthesia 2. anaesthetic agent consumption 3. time to recovery, extubation and quality of emergence 4. side effects and complications noted with the technique Timepoint: intraoperative postoperative	—

Countries

India

Contacts

Public Contactsujoy banik

ALL INDIA INSTITUTE OF MEDICAL SCIENCES(AIIMS), NEW DELHI, INDIA

girijarath.aiims@gmail.com9868398204

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026