Comparison between two drugs (bupivacaine and morphine) for relieving post operative pain after total hip replacement surgery in ankylosing spondylitis patients by administration through your lower back(caudal space)

Comparison of caudal morphine with bupivacaine or bupivacaine alone for post operative analgesia in patients with ankylosing spondylitis undergoing total hip replacement surgery under general anaesthesia.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/06/005869

Enrollment

Registered

2015-06-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients suffering from ankylosing spondylitis undergoing total hip replacement surgery.

Interventions

Intervention1: GROUP B: Administration of 0.125% bupivacaine 10 ml 8 hourly for 48 hours via catheter through caudal route for relief of postoperative pain in patients of ankylosing spondylitis under

Eligibility

Inclusion criteria

Inclusion criteria: i) Age > 18 and ii) ASA grade I & II patients. iii) Patients diagnosed to ankylosing spondylitis. iv) Patients scheduled for total hip replacement surgery

Exclusion criteria

Exclusion criteria: 1. ASA grade III / IV 2. History of bleeding /coagulation disorders. 3. Prolonged prothrombin time ( > 3 secs. as compared to control) or low platelet count ( 4. Revision THR surgery. 5. Pregnant patients 6. Morbid obesity ( BMI >= 40 kg/m2 ). 7. History of focal neurological deficit. 8. Congenital abnormality of sacrococcygeal area. 9. History of sensory or motor disorders of limb to be operated. 10. Patients with active infection at site of caudal block. 11. History of allergy to local anaesthetics. 12. History of regular opioid use. 13. Inability to comprehend VAS assessment scale. 14. Inability to understand the use of patient controlled analgesia (PCA) device

Design outcomes

Primary

Measure	Time frame
1) To compare the efficacy of 0.125% bupivacaine alone or in combination with 50 mcg/kg of morphine administered via caudal route for relief of postoperative pain in patients of ankylosing spondylitis under going total hip replacement surgery.Timepoint: 48 hours	—

Secondary

Measure	Time frame
1) To assess the success of catheter placement by comparing the length of caudal epidural catheter threaded without resistance as compared to the length predetermined by measuring the distance from apex of sacral hiatus to L2- L3 interspaceTimepoint: 48 hours;2) To confirm radiologically, the vertebral level to which the epidural catheter has reached.Timepoint: 48 hours	—

Countries

India

Contacts

Public ContactSUMIT BANSAL

AIIMS

MKARORA442@GMAIL.COM9868397806

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026