Health Condition 1: null- patients with coronary artery disease who have to undergo coronary artery bypass grafting under general anaesthesia
Conditions
Interventions
Intervention1: ivabradine: in study group,tab ivabradine 5mg BD to be started 3 days before surgery and given till the morning dose on the day of surgery. other medications i.e beta blockers, nitrate
Sponsors
G B Pant Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 2)primary CABG 3)Left ventricular Ejection Fraction 45% or more
Exclusion criteria
Exclusion criteria: • HR • Emergency surgery. • NYHA class IV. • Redo surgery. • Stroke or transient ischaemic attack • Implanted defibrillator, cardioverter or pacemaker • Associated valvular heart disease • Sick sinus syndrome • Sino-atrial block • Congenital long QT • Complete atrioventricular block • Severe or uncontrolled hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate, systolic blood pressure,diastolic blood pressure,mean blood pressureTimepoint: every 10 minutes from induction till start of coronary anastomosis.during coronary anastomosis every 5 minutes. after anastomosis evey 10 minutes till the closure of chest. | — |
Secondary
| Measure | Time frame |
|---|---|
| level of troponin T and Brain Natriuretic PeptideTimepoint: 12 hours postoperatively;morbidity and mortalityTimepoint: upto 30 days from date of operation;time to extubateTimepoint: after shifting in icu;untoward incidences like arrthymias or arrestTimepoint: till the patient in the hospital;central venous pressure , mean pulmonary arterial pressure, pulmonary capillary wedge pressure,stroke index, cardiac index, systemic vascular resistance index,pulmonary vascular resistance index, left ventricular stroke work index,right ventricular stroke work index,mixed venous oxygen saturationTimepoint: before induction,3 minutes after induction, 1 and 3 minutes after intubation,5 and 30 minutes after protamine | — |
Countries
India
Contacts
Public ContactVishwanath Mohire
Maulana Azad Medical College & associated G B Pant Hospital
Outcome results
None listed