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Effect of propofol-fentanyl, propofol-midazolam and propofol-dexmedetomidine combination on pulse rate, blood pressure and postoperative recovery for endoscopic procedure

Comparative evaluation of propofol-fentanyl, propofol-midazolam and propofol-dexmedetomidine on haemodynamic and postoperative recovery for endoscopic retrograde cholangiopancreatography: A prospective, randomized controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/06/005842
Enrollment
93
Registered
2015-06-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA grade I or III patient, Non diabetic, Non hypertensive and require Endoscopic retrograde cholangiopancreatography

Interventions

Intervention1: propofol-fentanyl: Fentanyl 1mcg/kg over 2 min, followed by propofol loading dose 1-2 mg/kg before procedure over a period of 2 min and maintenance infusion at a rate of 1-3 mg/kg/h thr

Sponsors

Apollo Hospitals Bilaspur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and III

Exclusion criteria

Exclusion criteria: 1.Patients with known sensitivity to study drugs 2.History of drug or alcohol abuse, 3.Morbid obesity (body mass index >40), 4.History of chronic pain or daily intake of analgesics 5.Oral anticoagulant use (warfarin) 6.Patients with bleeding diathesis 7.Impaired kidney or endocrinal functions 8.Pregnant patients and 9.Psychiatric patients

Design outcomes

Primary

MeasureTime frame
Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and oxygen saturation (SpO2)Timepoint: Basal, After study drug, After induction, at various time intervals during procedure, After procedure

Secondary

MeasureTime frame
Total dose of propofol,Postoperative recovery in between two groups (modified Aldrete score) and any complication Timepoint: During and After procedure

Countries

India

Contacts

Public ContactDr Vinit Kumar Srivastava

Apollo Hospitals Bilaspur

drvinit75@gmail.com09755557539

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026