Health Condition 1: null- Term newborns with persistent pulmonary hypertension
Conditions
Interventions
Intervention1: oral sildenafil given: Oral sildenafil tablet 1mg/kg/dose was given 6 hourly through orogastric tube for 5days.
Control Intervention1: Oral sildenafil was not given: Control group recei
Sponsors
Vivekananda Institute Of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: term newborns diagnosed to have persistent pulmonary hypertension on the basis of clinical and echocardiographic criteria .
Exclusion criteria
Exclusion criteria: 1.Preterm with RDS 2.Surgical cases like congenital diaphragmatic hernia 3.Major congenital anomaly including congenital heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Improvement in DOWNEâ??S score 2.Improvement in oxygenation index in ventilated babies and oxygen requirement in nonventilated babies 3.Echo criteria-decrease in peak pulmonary pressure in terms of tricuspid regurgitation gradient Timepoint: 1.Improvement in DOWNEâ??S score by day 5 of start of therapy 2.Improvement in oxygenation index in ventilated babies and oxygen requirement in nonventilated babies by day 5 of start of therapy 3.Echo criteria-decrease in peak pulmonary pressure in terms of tricuspid regurgitation gradient by day 5 of start of therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects of sildenafil like hypotension,hyperthermiaTimepoint: Two years | — |
Countries
India
Contacts
Public ContactProfAsha Mukherjee
Vivekananda Institute Of Medical Sciences,Ramakrishna Mission Seva Pratisthan
Outcome results
None listed