Health Condition 1: H160- Corneal ulcer Health Condition 2: null- Patients with moderate corneal ulcers between 2mm to 8mm
Conditions
Interventions
Intervention1: Gatifloxacin 0.3 % eye drops: Route is topical. Dose is 0.3 %. The dosage schedule was as follows. For the first 72 hours, antibiotics were given every hour, day and night. After 72 hou
Sponsors
RPC AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: Bacterial corneal ulcers measuring 2 to 8 mm giving written informed consent.
Exclusion criteria
Exclusion criteria: Bacterial corneal ulcers measuring less than 2 mm or more than 8 mm. Patients with suspected fungal, viral, or acanthamoeba ulcers and patients with known allergy to fluoroquinolones, aminoglycosides, penicillins, or cephalosporins were excluded from the study. Pregnant and lactating women and patients younger than 12 years also were excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Healing was defined as closure of the epithelial defect with disappearance of the stromal infiltrates at or before 3 months. Clinical response to medication was poor if the ulcer size remained the same or increased for 72 hours. If the patientâ??s keratitis worsened, the treatment code was broken, and the patient was administered a treatment regimen deemed fit by the investigator. Timepoint: Time point will be 3 months. Healing was defined as closure of the epithelial defect with disappearance of the stromal infiltrates at or before 3 months. Clinical response to medication was poor if the ulcer size remained the same or increased for 72 hours. If the patientâ??s keratitis worsened, the treatment code was broken, and the patient was administered a treatment regimen deemed fit by the investigator. | — |
Secondary
| Measure | Time frame |
|---|---|
| Final best-corrected visual acuity and resolution of infiltrates.Timepoint: 3 months | — |
Countries
India
Contacts
Public ContactNamrata Sharma
Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS
Outcome results
None listed