Use of drugs to control blood pressue in mothers of babies having oxygen problems during the surgery of mother for birth of the baby.

A randomized trial comparing prophylactic phenylephrine vs ephedrine infusion during spinal anesthesia for cesarean delivery in case of fetal compromise.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2015/05/005777

Enrollment

Registered

2015-05-14

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA I-II pregnant women aged 20-40 years taken up for emergency CD for acute fetal compromise under spinal anesthesia

Interventions

Intervention1: phenylephrine prepared in a 50ml syringe with concentration of 30Âµg/ml Rescue boluses were prepared similarly in identical 10 cc syringes to deliver P @ 50Âµg/ml: Baseline infusion was

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant women undergoing emergency CD for acute fetal compromise under SA were recruited in this study.Acute fetal compromise included 1) non reassuring fetal heart rate (FHR): those cases which had a reassuring fetal heart status at the beginning of labor and later on showed Category 2 cardiotocograph trace with no improvement following intrauterine resuscitative measures. ref 2 Fetal growth restriction (FGR) requiring emergency cesarean delivery were included if the subject was near term pregnancy with fetal biophysical profile (BPP) > than 6 before induction of labour and later on showed category 2 trace. 3) Ante/intrapartum hemorrhage.

Exclusion criteria

Exclusion criteria: Patients who had contraindications for SA, cardiovascular or cerebrovascular diseases, congenital fetal abnormalities, diabetes mellitus, chronic hypertension, mild or severe preeclampsia, multiple gestation, gestational age < 28-34 weeks , growth restricted fetuses having chronic asphyxia (previous abnormal non stress test and BPP <6)

Design outcomes

Primary

Measure	Time frame
primary outcome of the study was to assess the incidence of fetal acidosis. Apgar score , need for immediate neonatal resuscitation, maternal hemodynamics and adverse effects, if any were the secondary outcomes assessed.Timepoint: From the double clamped segments of cord, heparinized samples were taken from umbilical artery and vein soon after delivery of the baby.	—

Secondary

Measure	Time frame
Apgar score, need for immediate neonatal resuscitation and maternal hemodynamicsTimepoint: During and after delivery	—

Countries

India

Contacts

Public ContactKAJAL JAIN

POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH, CHANDIGARH, INDIA

kajalteji@gmail.com9814528468

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026