Health Condition 1: null- PATIENTS SUFFERING FROM CERVICAL SPINE SPONDYLOSIS OR PROLAPSED INTERVERTEBRAL DISC AT CERVICAL SPINE LEVEL, AND UNDERGOING ANTERIOR CERVICAL DISCECTOMY AND FUSION SURGERY (ACDF)
Conditions
Interventions
Intervention1: DEXMEDETOMIDINE INFUSION: IV infusion of dexmedetomidine (1µ/kg bolus over 10 min followed by 0.2 µg/kg/h as maintenance) started before induction of anaesthesia and continued till co
Sponsors
ALL INDIA INSTITUTE OF MEDICAL SCIENCES NEW DELHI
DR ARVIND CHATURVEDI
DR MIHIR PRAKASH PANDIA
PROF PARMOD KUMAR BITHAL
Eligibility
Inclusion criteria
Inclusion criteria: 64 adults of both sexes with the American Society of Anaesthesiologists (ASA) physical status I or II, aged 18 to 60 years, undergoing elective anterior cervical spine surgery for cervical spondylosis or prolapsed intervertebral disc were enrolled
Exclusion criteria
Exclusion criteria: Exclusion criteria included active smokers (history of smoking any time in past 6 months); preexisting bradycardia (HR below 50/min) or hypotension (systolic arterial pressure less than 100 mm Hg); planned elective ventilation post-operatively; poor respiratory reserve and poor cough reflex; presence of cardiac, renal, hepatic, and respiratory dysfunction; cognitive impairment; pregnancy or breast feeding; known allergy to alpha 2-agonists; and use of beta-blockers, cimetidine, digoxin, alpha 2-agonists or psychotropic medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure of this study was to assess post-operative recovery profile based on time to emergence.Timepoint: Emergence time was defined as time interval between discontinuing of anaesthetic agent and eye opening of patient either spontaneously or on verbal commands. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures included severity of coughing on emergence, time to attain Modified Aldrete Score (MAS) more than or equal to 9, total intraoperative sevoflurane/ fentanyl consumption, postoperative pain, time to first analgesic requirement in the postoperative period, perioperative haemodynamics, and incidence of postoperative complications including nausea, vomiting, shivering, and respiratory depression.Timepoint: at extubation, at ICU admission, till patient needed first analgesic dose in ICU | — |
Countries
India
Contacts
Public ContactDR VARUN JAIN
ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI
Outcome results
None listed