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Evaluation of effect of addition of magnesium sulphate to bupivacaine for spinal anaesthesia in pregnant women

A Randomised Controlled Double-blind trial to evaluate the effect of addition of intrathecal magnesium sulphate to hyperbaric bupivacaine on postoperative pain after lower segment caesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2015/05/005749
Enrollment
100
Registered
2015-05-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 0.1 ml 50% magnesium sulphate: 2ml 0.5% hyperbaric bupivacaine + 0.1 ml of 50% magnesium sulphate (50 mg)(study) Control Intervention1: 0.1 ml normal saline: 2ml 0.5% hyperbaric bupivac

Sponsors

Lady Hardinge Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II parturients Undergoing lower segment Caesarean section

Exclusion criteria

Exclusion criteria: patient refusal any contraindication to regional anaesthesia weight >90kg height 170cm known allergy to local anaesthetic or magnesium sulphate dysrrthymias in ECG or any systemic disorder history of chronic pain already on magnesium therapy severe psychiatric disturbance history of drug abuse unable to communicate in either hindi or english

Design outcomes

Primary

MeasureTime frame
Prolongation in duration of postoperative analgesia with addition of intrathecal magnesium sulphate to hyperbaric bupivacaine as compared to hyperbaric bupivacaine with normal salineTimepoint: time interval between administration of intrathecal block and first request for analgesia by patient(visual analog score more than 4 ) was noted—

Secondary

MeasureTime frame
Onset of sensory & motor block was slower while duration of sensory as well as motor block was prolonged with magnesium sulphate group. Neonatal APGAR scores and incidence of side-effects were comparable in the two groupsTimepoint: Continuous ECG,HR,SpO2 were monitored. Non-invasive BP,PR & level of sedation at every 3min interval till delivery of baby,thereafter at 5min interval till end of surgey,postop at 30min interval for first 2hr then hourly till first recue analgesic Onset of sensory block- from time of block till T6(pin-prick method) Onset of motor block-till Bromage scale 3 reached APGAR score-at 1 and 5 min Duration of sensory blocktime till T12 reached Duration of motor block-till Bromage scale 0 reached—

Countries

India

Contacts

Public ContactSUSHMITA ROY

Lady Hardinge Medical College, New Delhi

lhmcanaesthesia@gmail.com8588837010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026