Health Condition 1: null- New-onset,Infrequently relapsing nephrotic syndrome
Conditions
Interventions
Intervention1: STUDY ARM B
Calcium and Vitamin D: Elemental calcium 500mg,Vitamin D 400 iu per day
for 6 weeks in infrequently relapsing nephrotic syndrome ,3 months in case of new-onset nephrotic syn
Sponsors
JIPMER Intramural fund
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria : Children with new- onset and infrequently relapsing nephrotic syndrome receiving steroids, attending pediatric nephrology clinic and pediatric wards, JIPMER
Exclusion criteria
Exclusion criteria: Exclusion criteria : i) Children with history of hypocalcemic seizure, tetany, rickets or fractures. ii) Known cases of renal stones. iii) Children with NS already on calcium and vitamin D supplements. iv) Sexual maturity rating (SMR grade 2, by Tanner staging) and above. v) Frequently relapsing, steroid dependent and steroid resistant NS. vi) Children on cyclosporine therapy, phenytoin, phenobarbitone, methotrexate or requiring any immunosuppressant other than prednisolone. vii) Chronic renal failure or chronic liver disease. viii) Secondary causes of NS (e. g IgA nephropathy, Henoch Schonlein Purpura nephritis ,Lupus nephritis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral contentTimepoint: Before and after steroid therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| i)serum 25-hydroxy-cholecalciferol ii)Bone Mineral Density iii)serum calcium, phosphate and alkaline phosphatase iv)serum intact parathormone (iPTH) levels Timepoint: Before and after steroid therapy | — |
Countries
India
Contacts
Public ContactDrSriram krishnamurthy
JIPMER
Outcome results
None listed