Health Condition 1: null- Neonate admitted with evidence of bacterial meningitis
Conditions
Interventions
Intervention1: oral glycerol: 1.5 ml/kg/dose every 6 hourly for 48 hours
Control Intervention1: Standard Treatment Alone: Standard treatment group patient will not receive the study drug (oral glycero
Sponsors
The Director
Eligibility
Inclusion criteria
Inclusion criteria: Neonate (32 cells/mm3)
Exclusion criteria
Exclusion criteria: 1. Neonates who received >= 2 doses of parenteral antibiotics. 2. History of birth asphyxia irrespective of hypoxic ischemic encephalopathy (HIE) stage. 3. Associated condition known to cause developmental delay like bilirubin encephalopathy, congenital malformation, syndromic neonate. 4. Known or suspected case of hearing loss. 5. Contraindication for enteral feeding like septic ileus, intestinal obstruction, necrotizing entercolitis (NEC). 6. Neonates in whom lumbar puncture is contraindicated (bleeding diathesis etc) 7. Gestation age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite outcome of death, severe neurological sequelae) and hearing loss.Timepoint: Composite outcome of death, severe neurological sequelae) and hearing loss. | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of intensive care unit stay.Timepoint: At ICU discharge.;Length of mechanical ventilation if ventilatedTimepoint: At extubation from ventilation.;Progression of systemic inflammatory response syndrome (SIRS)Timepoint: 48 hours;Length of hospital stayTimepoint: At hospital discharge.;Functional status (including hearing assessment)Timepoint: At 3 months. | — |
Countries
India
Contacts
Public ContactDr Ramesh Kumar R
JIPMER
Outcome results
None listed