Health Condition 1: null- Chronic end stage liver disease with cirrhosis Health Condition 2: K730- Chronic persistent hepatitis, notelsewhere classified
Conditions
Interventions
Intervention1: End-tidal desflurane concenteration: After endotracheal intubation desflurane vaporizer dial concentration will be set to 6 vol% and delivered to the patient with an oxygen flow of 1-l/
Sponsors
Sir Ganga Ram Hospital
Eligibility
Inclusion criteria
Inclusion criteria: End stage liver disease cirrhosis requiring liver transplant
Exclusion criteria
Exclusion criteria: 1. Hepatic encephalopathy at time of surgery. 2. Acute and fulminant hepatic failure. 3. Hepatorenal syndrome. 4. Preoperatively on ventilator. 5. Requiring intraoperative veno-venous bypass. 6. Sensitivity to any drug used perioperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine bispectral index targeted end-tidal desflurane concentration during the three phases of orthotopic liver transplant. Timepoint: From induction of anaesthesia till end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the relationship between inhalational anaesthetic requirement and severity of liver disease among orthotopic liver transplant recipients. Timepoint: From induction of anaesthesia till end of surgery;To study the effect of changes in mean arterial pressure and body temperature on BIS targeted end-tidal desflurane concentration during the three phases of liver transplantationTimepoint: From induction of anaesthesia till end of surgery | — |
Countries
India
Contacts
Public ContactDr Nitin Sethi
Sir Ganga Ram Hospital
Outcome results
None listed